Sirtuins are NAD⁺-dependent protein deacetylases and ADP-ribosyltransferases that regulate metabolism, stress resistance, genomic stability, and longevity across all domains of life. Click any card to explore.
Each hallmark of aging is regulated by one or more sirtuins. This bidirectional relationship makes sirtuins prime therapeutic targets for longevity interventions.
Each sirtuin operates in a specific cellular compartment. SIRT1, 6, 7 reside in the nucleus; SIRT2 shuttles between cytoplasm and nucleus; SIRT3, 4, 5 reside in mitochondria. Hover over each sirtuin to see its primary activities.
Interactive network showing connections between sirtuins, their key substrates, upstream regulators, and downstream effectors. Click a node to highlight its connections.
Relative mRNA expression levels of SIRT1–7 across major human tissues. Data derived from GTEx and Human Protein Atlas consensus datasets.
Data: Human Protein Atlas + GTEx v8
Trend data from longitudinal aging cohort studies (Horvath et al., Lu et al.)
Reviewed in: Rajman et al. Cell Metab. 2018; Yoshino et al. Cell Metab. 2022
Compounds and lifestyle interventions that modulate sirtuin activity, from NAD⁺ precursors to caloric restriction mimetics. Includes clinical trial status and known targets.
| Compound | Class | Target(s) | Mechanism | Stage | Key Finding |
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Camacho-Pereira et al. Cell Metab. 2016; Massudi et al. PLoS ONE 2012
Sirtuins play dual roles as both tumor suppressors and oncogenes depending on context. Recent work (Ungvari et al. 2026) reveals subtype-specific sirtuin expression signatures linking mitochondrial-epigenetic networks to breast cancer survival.
Ungvari Z, et al. Geroscience. 2026. PMID: 41692938